The world’s most advanced interactive methylation-pathway tool. Built for practitioners, educators, and curious minds who want to see how the entire system actually works.
The Methylation Map
See Your Biology in Motion
Why it Exists
Because no one should learn methylation the hard way.
Practitioners kept asking the same question:
“How do all these pathways actually fit together?”
For years, methylation has been taught in fragments – one cycle here, one enzyme there, a scattered diagram in a course, a random PDF in a module. But nothing showed the true interconnected system that drives energy, mood, detoxification, neurotransmitters, inflammation, and genetic expression.
The Methylation Map was created to solve that problem.
It shows the four major cycles – Methionine, Folate, BH4/Neurotransmitter, and Urea – plus the Transsulfuration Pathway and the energy-driving Krebs Cycle, all working together. You can finally see how each system connects, where things get stuck, and why symptoms appear the way they do.
Every enzyme, cofactor, inhibitor, metabolite, neurotransmitter, and clinical insight is placed in context – supported by 100+ practitioner pop-ups that explain what each step means for chronic fatigue, anxiety, autism, hormone imbalance, cardiovascular risk, methylation issues, gut dysfunction, and mitochondrial collapse.
This map is a living tool – continually updated as new pathways, enzymes, and clinical strategies emerge.
This is the tool I wish had existed when I first tried to understand methylation.
Now it exists so practitioners can finally see the whole system clearly.
Open the Interactive Demo
Take a look inside the map and experience how quickly complex biochemistry becomes clear.
The demo lets you zoom into the core systems – BH4/Neurotransmitters, Methionine, Folate, Urea, and the Transsulfuration Pathway – and also explore how energy and methyl donors move through the system. You can watch dopamine and serotonin shift as BH4 rises or drops, see how methyl groups flow into detoxification, and follow how the Krebs Cycle powers everything behind the scenes.
What you’ll notice immediately:
✅ Every pathway is connected – nothing stands alone
✅ Clicking reveals deeper layers – cofactors, roadblocks, and clinical implications
✅ Intermediates like methionine and homocysteine finally make sense.
NOTE: The demo reflects an earlier version of the Methylation Map. The full Practitioner Edition has been significantly expanded with new pop-ups, updated pathways, and integrated Practitioner Insight PDFs that are not shown in the demo.
👉 Open the demo below and get a feel for how powerful this tool becomes in real clinical use.
💡 For full interactivity, open the demo in a PDF viewer such as PDF-XChange Editor (Free) or Adobe Acrobat Reader
🔒 The Interactive demo map is hosted securely through our Shopify store.
Ready to Go Beyond the Demo?
The Practitioner Edition unlocks the full system – every enzyme, every cofactor, every neurotransmitter, every pathway, and every Practitioner Insight PDF woven into the map. It transforms biochemistry into something you can actually see, teach, and use clinically.
Here’s what the full edition gives you:
👉 Full Interactivity & Depth: Every enzyme, cofactor, inhibitor, metabolite, and neurotransmitter is clickable. Pop-ups layer in clinical meaning, decision points, and biochemical context that doesn’t exist in the demo.
👉 Massively Expanded Coverage: Includes the complete Methionine, Folate, BH4/Neurotransmitter, and Urea Cycles, plus the Transsulfuration Pathway, Krebs Cycle, and the mineral–mitochondrial foundation that stabilizes methylation. All upgraded and refined in the latest version.
👉 Practitioner Insight Blocks + PDF Reports: Exclusive to the Practitioner Edition – embedded clinical explanations, treatment hierarchy frameworks, sulfur and cysteine insights, histamine patterns, over/under-methylation guidance, and more. Each Insight opens into a structured PDF for deeper teaching and case review.
👉 Professional-Grade Usability: Built for live consults, case reviews, practitioner training, teaching programs, and deep self-study. The map becomes the backbone for explaining energy, mood, hormones, detox, and mitochondria in one unified model.
👉 Real Clinical Pattern Recognition: See how methylation misfires ripple into fatigue, anxiety, estrogen issues, poor detox, sulfur overload, neurotransmitter imbalance, and mitochondrial strain – all in one place.
If you work with chronic fatigue, mood disorders, autism-spectrum patterns, digestive dysfunction, hormone imbalances, cardiovascular risk, or mitochondrial instability – this map finally lets you see your clients’ chemistry as one connected story.
Click below to unlock the full Practitioner Edition.
Why This Is a $1,497 Practitioner Tool
This isn’t a simple pathway diagram; it’s a complete visual teaching system built from years of clinical work, research, and real-world case interpretation.
Most practitioners struggle to explain methylation because the information is scattered everywhere: one book covers neurotransmitters, another explains sulfur pathways, another talks about homocysteine…but nothing shows how all of these moving parts actually fit together.
The Methylation Map finally brings the whole story into one place.
It connects the Methionine Cycle, Folate Cycle, BH4/Neurotransmitter Cycle, Urea Cycle, Transsulfuration Pathway, and the entire Krebs Cycle into one interactive model. Enzymes on the map display their cofactors, inhibitors, promoters, and outputs directly, so you can see metabolic flow at a glance.
And when deeper guidance is needed, Practitioner Insight blocks open into structured PDFs explaining clinical patterns, upstream/downstream logic, symptom clusters, and real-case interpretation. Many nodes also include embedded Practitioner PDFs inside pop-up windows, allowing you to explore complex topics like over- and under-methylation, sulfur overload, histamine pathways, methylfolate trapping, and more, all from within the map.
Practitioners use it to simplify complex cases, teach patients, improve compliance, and understand biochemistry at a deeper level than any textbook or course offers.
This tool replaces confusion with clarity, and that’s why it’s priced as a premium practitioner resource.
What the Map Reveals
Each interactive pop-up shows practitioners exactly:
• How all four core cycles integrate – Methionine, Folate, BH4/Neurotransmitter, and Urea – and how the Transsulfuration Pathway branches from Methionine to produce glutathione and manage sulfur.
• How neurotransmitters actually flow – dopamine → norepinephrine → epinephrine; serotonin; GABA; glutamate – and the enzymes with their cofactors, inhibitors, and promoters that control each step.
• Where nutrients really fit in the system (B2, B6, B12, folate, magnesium, zinc, copper, molybdenum) – not just what they do – but where they plug into the map and what happens when they’re missing.
• How methylation drives the system, influencing detoxification, inflammation, hormones, mitochondria, redox balance, nitric oxide production, and cellular repair.
• Where biochemical bottlenecks appear – and how they generate the real symptoms you see in practice: fatigue, anxiety, depression, histamine overload, estrogen issues, brain fog, sulfur intolerance, and poor stress handling.
This is the only interactive resource that connects enzymes, intermediates, neurotransmitters, inhibitors, oxidative stress, estrogen detox, nitric oxide, ammonia, and functional patterns; all in one place.
Real insights from those putting the Methylation Map to work.
What Practitioners Are Saying
From functional medicine practitioners to dedicated biohackers, the Methylation Map is transforming how individuals comprehend and teach the body's chemistry. Each perspective represents a unique way this visual tool makes complex science accessible.